Publications

The following is a table of publications related to mannitol and its use as a bronchial challenge agent. This list is updated regularly, with publications appearing in date order.  

Most of these papers have abstracts that are accessible through PubMed.


Mannitol as a Bronchial Provocation Test:

Authors

Title

Reference

Wood LG, Powell H, Gibson PG.

Mannitol challenge for assessment of airway responsiveness, airwayinflammation and inflammatory phenotype in asthma

Clinical and Experimental Allergy. 2009; 40:232-241 Clinical Study

Miedinger D, Mosimann N, Meier R, et al.

Asthma tests in the assessment of military conscripts

Clinical and Experimental Allergy 2009; 40: 224-231 Clinical Study

Anderson SD, Brannan JD.

Bronchial provocation testing and collection of sputum with inhaled mannitol

Clinical and Experimental Allergy 2009; 1-4 Editorial[K1]

Cockcroft D, Davis B.

Direct and indirect challenges in the clinical assessment of asthma

Ann Allergy Asthma Immunol. 2009 Nov;103(5):363-9. Review

Brannan JD, Porsbjerg C, Anderson SD

Inhaled mannitol as a test for bronchial hyperresponsiveness

Expert Rev Resp Med 2009; 3(5): 457-468[K4] Review

Porsbjerg C, Backer V, Joos G, et al.

Current and future use of the mannitol bronchial challenge in everyday clinical practice

Clin Resp J 2009; 3: 189-197

Sverrild A, Porsbjerg C, Thomsen SF, Backer V.J.

Diagnostic properties of inhaled mannitol in the diagnosis of asthma: a population study

Allergy Clin Immunol. 2009 Nov; 124:928-32[K3] Clinical Study

Spector, S.

Use of Mannitol Inhalation Challenge in Assessment of Cough

Lung, 2009 Sep 16 Epub ahead of print. Review[K2]

Sverrild A, Porsbjerg C, Thomsen SF, Backer V.

Diagnostic properties of inhaled mannitol in the diagnosis of asthma: A population study.

J Allergy Clin Immunol. 2009 Aug 7.

Porsbjerg C, Lund TK, Pedersen L, Backer V.

Inflammatory subtypes in asthma are related to airway hyperresponsiveness to mannitol and exhaled NO

J Asthma. 2009 Aug;46(6):606-12.

Horsman TA, Duke RK, Davenport PW.

Airway response to mannitol challenge in asthmatic children using impulse oscillometry.

J Asthma. 2009 Aug;46(6):600-3.

Kersten ET, Driessen JM, van der Berg JD, Thio BJ.

Mannitol and exercise challenge test in asthmatic children

Pediatr Pulmonol. 2009 Jul;44(7):655-61.

Cockcroft DW, Davis BE.

Diagnostic and therapeutic value of airway challenges in asthma

Curr Allergy Asthma Rep. 2009 May;9(3):247-53. Review

Lund TK, Pedersen L, Anderson SD, Sverrild A, Backer V.

Are asthma like symptoms in elite athletes associated with classical features of asthma.

Br J Sports Med. 2009 Feb 6

O'Byrne PM, Gauvreau GM, Brannan JD.

Provoked models of asthma: what have we learnt?

Clin Exp Allergy. 2009 Feb;39(2):181-92. Review

Anderson SD, Charlton B, Weiler JM, Nichols S, Spector SL, Pearlman DS; A305 Study Group.

Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma

Respir Res. 2009 Jan 23;10:4.

Muñoz PA, Gómez FP, Manrique HA, Roca J, Barberà JA, Young IH, Anderson SD, Rodríguez-Roisin R.

Pulmonary gas exchangeresponse to exercise- and mannitol-induced bronchoconstriction in mild asthma

J Appl Physiol. 2008 Nov;105(5):1477-85. Epub 2008 Aug 28

Rundell KW, Slee JB.

Exercise and other indirect challenges to demonstrate asthma or exercise-induced bronchoconstriction in athletes

J Allergy Clin Immunol. 2008 Aug;122(2):238-46; quiz 247-8. Review.

Anderson SD.

Provocation challenges to help diagnose and monitor asthma: exercise, methacholine, adenosine and mannitol.

Curr Opin Pulm Med. 2008 Jan;14(1):39-45. Review

Porsbjerg C, Brannan JD, Anderson SD, Backer V.

Relationship between airway responsiveness to mannitol and to methacholine and markers of airway inflammation, peak flow variability and quality of life in asthma patients.

Clin Exp Allergy. 2008 Jan;38(1):43-50. Epub 2007 Nov 19

Schafroth Török S, Leuppi JD.

Bronchial hyperresponsiveness and exhaled nitric oxide in chronic obstructive pulmonary disease

Swiss Med Wkly. 2007 Jul 14;137(27-28):385-91. Review.

Miedinger D, Chhajed PN, Tamm M, Stolz D, Surber C, Leuppi JD.

Diagnostic tests for asthma in firefighters

Chest. 2007 Jun;131(6):1760-7. Epub 2007 Mar 30.

Stolz D, Anderson SD, Gysin C, Miedinger D, Surber C, Tamm M, Leuppi JD.

Airway reactivity to inhaled mannitol in cigarette smokers: a longitudinal study

Respir Med. 2007 Jul;101(7):1470-6. Epub 2007 Feb 26.

Porsbjerg C, Rasmussen L, Thomsen SF, Brannan JD, Anderson SD, Backer V.

Response to mannitol in asymptomatic subjects with airway hyper-responsiveness to methacholine.

Clin Exp Allergy. 2007 Jan;37(1):22-8.

Haney S, Hancox RJ.

Recovery from bronchoconstriction and bronchodilator tolerance

Clin Rev Allergy Immunol. 2006 Oct-Dec;31(2-3):181-96. Review.

Gulliksson M, Palmberg L, Nilsson G, Ahlstedt S, Kumlin M.

Release of prostaglandin D2 and leukotriene C4 in response to hyperosmolar stimulation of mast cells.

Allergy. 2006 Dec;61(12):1473-9.

Menzies D, Nair A, Lipworth BJ.

Non-invasive measurement of airway inflammation in asthma

J Asthma. 2006 Aug;43(6):407-15. Review.

Brannan J.D,1, Gulliksson M, Anderson SD, Chew N, Seale JP, Kumlin M

Inhibition of mast cell PGD2 release protects against mannitol-induced airway narrowing

Eur Respir J 2006; 27: 944—950

Sak I, Kurzawa R, Nowosielska A.

Bronchial challenges in asthma control

Przegl Lek. 2005;62(12):1488-93. Review. Polish

Anderson SD

Best indicators of asthma control; Asthma biomarkers including spirometry

AAAI 2006, Session 5533 workshop presentation

Stolz D, Gysin C, Miedinger D, Tandjung R, Surber C, Tamm M, Leuppi J

Airway responsiveness to inhaled mannitol is increased in smokers and decreases after short term smoking cessation

CHEST / 128 / 4 / October, 2005 Supplement

Brannan JD, Anderson SD, Perry CP, Freed-Martens R, Lassig AR, Charlton B and the Aridol Study Group

The safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline

Respiratory Research 2005, 6:144

Carlson KH; taskforce on recognising and diagnosing exercise related asthma, respiratory and allergic disorders in sport.In: Diagnosis and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports.

Evidence based recommendations for the diagnosis of exercise induced asthma in athletes.

Carlsen K-H, Delgado L, Del Giacco S, Eds. Eur Respir Mon: European Respiratory Society, 2005;10(33);Chpt 10

Anderson SD, Bruscasco V, Haahtela T, Popov T.In: Diagnosis and Treatment of Exercise-Related Asthma, Respiratory and Allergic Disorders in Sports.

Criteria for diagnosis of asthma, EIB and AHR for athletes: lessons from the Olympic Games

Carlsen K-H, Delgado L, Del Giacco S,Eds. Eur Respir Mon: European Respiratory Society, 2005; 10(33); Chpt 6

Koskela H, Martens R, Brannan JD, Anderson SD, Leuppi JD, Chan H-K.

Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects

Respirology (2005) 10, 442—448

Anderson S.D, Brannan J.D, Koskela H, Leuppi J.D

Monitoring Airway Hyperresponsiveness: Indirect Stimuli—Exercise, Hypertonic Saline, Mannitol, and AMP

Monitoring Asthma ed. Gibson PG; Taylor and Francis Group, Boca Raton USA

Anderson S.D, Brannan J.D, Freed-Martens R.H, and The Aridol Study Group.

Bronchial provocation using inhaled mannitol - a phase 3 trial of paediatric asthmatics and non-asthmatics

ATS 2005 Abstract #955218

Brannan J.D, Anderson S.D, Freed-Martens R.H, and The Aridol Study Group.

Bronchial provocation using inhaled mannitol - a phase 3 trial of adult asthmatics and non-asthmatics

ATS 2005 Abstract #953009

Freed-Martens R, Anderson S.D, Brannan J.D, Aridol study group

Effect of treatment on recovery of FEV1 to baseline after a mannitol challenge: a phase 3 study

Australian New Zealand Soc Resp Sci ASM 2005 Abst.

Anderson S.D

Bronchoprovocation Challenges: The How To's

Session 4701: AAAAI San Antonio Texas 2005 (Pres.)

Anderson S.D

Theory and Rationale for bronchial provocation studies in asthma

Session 2714: AAAAI San Antonio Texas 2005 (Pres.)

Anderson S.D, Brannan J.D, Koskela H, Freed-Martens R, Leuppi J.D, Holzer K, Lipworth B, Currie K, Sue-Chu M, Perry C.P.

Provoking Dose Of Mannitol To Assess Airway Hyperresponsiveness In Asthma: A Retrospective Analysis

Abstract No: 1460 AAAAI ASM 2005 (Poster)

Leuppi J.D, Tandjung R, Anderson S.D, Stolz M.H, Brutsche M.H, Bingisser R, Perruchoud A.P, Surber C, Knoblauch A, Andersson M, Greiff L, Chan H-K, Tamm M

Prediction of treatment-response to inhaled corticosteroids by mannitol-challenge test in COPD. A proof of concept

Pulmonary Pharmacology & Therapeutics 18 (2005) 83—88

Barben J, Riedler J

Measurement of Bronchial Responsiveness in Children

Paed Pulm Function Testing. Prog Respir Res. Basel, Karger, 2005, vol 33, pp 125—136

Tandjung R, Anderson S.D, Brutsche M.H, Bingisser R, Perruchoud A.P, Surber C, Tamm M, Leuppi J.D

Prediction of Treatment-Response to Inhaled Corticosteroids by Mannitol-Challenge Test in COPD

Poster 502 ATS 2004

Lee DK

Airway hyperresponsiveness to bronchial mannitol: where do we go from here?

Chest . 2004 Jul;126(1):318-9; author reply 319-20.

D. Jaccard-Stolz, M. Tamm, S.D. Anderson, C. Suber, J.D. Leuppi

Bronchial Hyperreactivity to Mannitol before and after Smoking Cessation

Poster K28 ATS 2004

Koskela H.O, Hyv?rinen L, Brannan J.D, Chan H-K, Anderson S.D.

Coughing During Mannitol Challenge Is Associated With Asthma

Chest 2004; 125:1985—1992

Currie G.P, Jackson C.M, Lipworth B.J

Does Bronchial Hyperresponsiveness in Asthma Matter?

J of Asthma Vol. 41, 3, pp. 247—258, 2004

Gulliksson M, Brannan J.D, Anderson S.D, Seale P.J, Delin I, Kumlin M.

Inhibition of the airway response to mannitol with either eformoterol or sodium cromoglycate (SCG) does not alter leukotriene release in asthmatic subjects

Eur Resp J, 2004; 24: 443s ;P2735

Leuppi J.D, Tandjung R, Anderson S.D, Brutsche M.H, Surber C, Bingisser R, Perruchoud A.P, Tamm M

An indirect bronchoprovocation challenge test using the dry powder Mannitol in mild COPD-patients

Poster ERS Vienna 2003

Brannan JD, Anderson SD, Perry CP, Kippelen P, Freed R, Holzer K, Sue-Chu M

Bronchial Provocation Tests using a Dry Powder of Mannitol in Asthmatic and Healthy Subjects with Normal Spirometry

VIIth IOC World Congress on Sports Science Athens, Greece October 2003

Joos G.F (Chairman), O'Connor B (Co-Chairman), Anderson S.D, Chung F, Cockcroft D.W, Dahlen B, DiMaria G, Foresi A, Hargreave F.E, Holgate S.T, Inman M, L?tvall J, Magnussen H, Polosa R, Postma D.S, Riedler J.

ERS Task Force Report: Indirect airway challenges

Eur Respir J 2003; 21: 1050—1068

Barben J, Roberts, Chew N, Carlin J.B, Robertson C.F

Repeatability of Bronchial Responsiveness to Mannitol Dry Powder in Children With Asthma

Pediatric Pulmonology 36:490—494 (2003)

Brannan JD

Inhaled Mannitol ; A new Bronchial Provocation Test to assess the presence and severity of asthma.

RT International, Fall 2003: 29-3142.

Lee DK, Haggart K, Currie GP, Anderson SD, Lipworth BJ.

The effects of histamine and leukotriene receptor antagonism on nasal mannitol challenge in allergic rhinitis.

Br J Clin Pharmacol 2003; 55(6):639-642.

Brannan JD, Gulliksson M, Anderson SD, Chew N, Kumlin M.

Evidence of mast cell activation and leukotriene release after mannitol inhalation.

Eur Respir J 2003; 22(3):491-496

Koskela H.O; Hyv?rinen L; Brannan J.D; Chan H.K; Anderson S.D

Responsiveness to Three Bronchial Provocation Tests in Patients With Asthma

Chest 2003; 124:2171—2177

Koskela HO, Hyv?rinen L, Brannan JD, Chan H-K, Anderson SD.

Sensitivity and validity of three bronchial provocation tests to demonstrate the effect of inhaled corticosteroids in asthma.

Chest 2003; 124(4):1341-1349.

Currie GP, Haggart K, Brannan JD, Lee DKC, Anderson SD, Lipworth BJ.

Relationship between airway hyperresponsiveness to mannitol and adenosine monophosphate.

Allergy 2003 58:762-766

Currie GP, Haggart K, Lee DKC, Fowler SJ, Wilson AM, Brannan JD, Anderson SD, Lipworth BJ.

Effects of mediator antagonism on mannitol and adenosine monophosphate challenges.

Clin Exp Allergy 2003; 33:783-788.

Anderson SD, Brannan JD.

Methods for 'indirect' challenge tests including exercise, eucapnic voluntary hyperpnea and hypertonic aerosols.

Clin Rev Allergy Immunol 2003; 24: 27-54.

Holzer K, Anderson SD, Chan H-K, Douglass J.

Mannitol as a challenge to identify exercise-induced bronchoconstriction in elite athletes.

Am J Respir Crit Care Med 2003; 167: 534-537.

Holzer K, Anderson SD, Douglass J.

Exercise in Elite Summer Athletes: challenges for diagnosis.

J Allergy Clin Immunol 2002; 110: 374-380.

Anderson SD, Brannan JD, Chan HK.

Use of aerosols for bronchial provocation testing in the laboratory: Where we have been and where we are going.

J Aerosol Med 2002;15(3):313-324.

Leuppi JD, Brannan JD, Anderson SD.

Bronchial provocation tests: The rationale for using inhaled mannitol as a test for airway hyperresponsiveness.

Swiss Medical Weekly 2002; 132:151-158.

Brannan JD, Koskela H, Anderson SD, Chan H-K.

Budesonide reduces sensitivity and reactivity to inhaled mannitol in asthmatic subjects.

Respirology 2002; 7(1):37-44.

Leuppi JD. Salome CM, Jenkins CR, Koskela H, Anderson SD, Andersson M, Chan H-K, Woolcock AJ.

Markers of airway inflammation and airway hyperresponsiveness in patients with well-controlled asthma.

Eur Respir J 2001; 18(3):444-450.

Brannan JD, Anderson SD, Gomes K, King GG, Chan H-K, Seale JP.

Fexofenadine decreases sensitivity to and montelukast improves recovery from inhaled mannitol.

Am J Respir Crit Care Med 2001; 163: 1420-1425.

H?gman M, Lúdviksdóttir D,Anderson SD, George S, Hakansson L, Chan HK, Meril?inen,P, Hedenstr?m H.

Inhaled mannitol shifts exhaled nitric oxide in opposite directions in asthmatic and healthy subjects.

Respiration Physiology 2001; 124:141-150.

Leuppi JD. Salome CM, Jenkins CR, Anderson SD, Xuan W, Marks GB, Koskela H, Brannan JD, Freed R, Andersson M, Chan H-K, Woolcock AJ.

Predictive markers of asthma exacerbation during stepwise dose reduction of inhaled corticosteroids.

Am J Respir Crit Care Med2001; 163:406-412.

Koskela H, Di Sciascio M, Anderson SD, Andersson M, Chan H-K, GadallaS, Katelaris C.

Nasal hyperosmolar challenge with a dry powder of mannitol in patients with allergic rhinitis. Evidence for epithelial cell involvement.

Clin Exp Allergy 2000; 30(11):1628-1636.

Brannan JD, Anderson SD, Freed R, Leuppi JD, Koskela H, Chan H-K.

Nedocromil sodium inhibits responsiveness to inhaled mannitol in asthmatic subjects.

Am J Respir Crit Care Med 2000; 161; 2096-2099.

Subbarao P, Brannan JD, Ho B, Anderson SD, Chan H-K, Coates AL.

Inhaled mannitol identifies methacholine-responsive children with current asthma.

Pediatr Pulmonol 2000; 29:291-298.

Brannan JD, Koskela H, Anderson SD, Chew N.

Responsiveness to mannitol in asthmatic subjects with exercise- and hyperventilation-induced asthma.

Am J Respir Crit Care Med, 1998: 158:1120-1126.

Anderson SD, Brannan J, Spring J, Spalding N, Rodwell LT, Chan K, Gonda I, Walsh A, Clark AR.

A new method for bronchial-provocation testing in asthmatic subjects using a dry powder of mannitol.

Am J Respir Crit Care Med 1997; 156: 758-765.