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The mannitol challenge test (Osmohole®) is an indirect osmotic bronchial challenge test that can be used to identify bronchial hyperresponsivesness, a key clinical feature of respiratory conditions such as asthma.
Osmohole is manufactured by Pharmaxis Ltd (Frenchs Forest, Sydney Australia) and is available as a standardised test kit containing pre-filled mannitol capsules and a hand held dry powder inhaler.
During a mannitol challenge test, the subject inhales increasing doses of mannitol with their lung function (forced expiratory volume in one second- FEV1) measured after each dose to determine the level of bronchial hyperresponsiveness.
The mannitol challenge test should only be performed by a suitably trained healthcare professional. Please refer to the approved product information or summary of product characteristics for your country prior to performing this challenge test.
Please refer to the Approved Osmohale Product Information(PI) and Consumer Medicine Information attached below.
For more information about Osmohale in the United Kingdom please contact;
Pharmaxis Pharmaceuticals Ltd
Phone: 0114 254 3585
Fax: 0114 242 5573